Guruvayoor is well connected with the other parts of the country by road and rail. The National highway is passing through Kunnamkulam which is just 8 kms away from Guruvayoor. The private bus stand is towards the east of the temple, near Manjulal (the banyan tree). It is half an hour drive by car from Thrissur and busses ply every 5 minutes from Thrissur to Guruvayoor.
Kerala Road Transport Corporation (KSRTC) runs bus services from all major locations of the state and few inter-state services. The bus stand is 500 meters to the west of the temple. Both KSRTC and private busses offer interstate services to all major South Indian cities like Madras, Madurai, Palani, Salem, Coimbatore, Thiruchandoor, Mysore, Mangalore, Uduppi, Mookambika etc.
Guruvayoor has got a railway station towards the east of the temple which is connected to the Madras-Mangalore main line at Thrissur. It has got computerised ticket booking facility and tickets can be booked to any locations from here. One from the Mangalore side can get down at the Kuttippram station. Regular buss services are available from there to Guruvayoor. Those from the Madras/Trivandrum side can get down at Thrissur.
Kochi international airport (Nedumbassery) is 80 kms from Guruvayoor and the Calicut airport is 100 kms away. All major international flight services are operated from these airports.